Prakt. lékáren. 2005; 1(1): 16-17

Léčiva na bázi pyrazinu

doc. PharmDr. Martin Doležal Ph.D1,2
1 _
2 Farmaceutická fakulta, Hradec Králové

Synteticky připravené pyraziny jsou používány jako identická „vonidla“ či „chutidla“ v potravinářství, ve voňavkářství či v tabákovém průmyslu. Pyraziny mají celou škálu biologických účinků, používají se i jako důležitá léčiva. Historicky prvními byla sulfonamidová chemoterapeutika sulfapyrazin a jeho strukturní varianta sulfalen, velmi jednoduchým derivátem je stále významné antituberkulotikum pyrazinamid. Dalšími důležitými léčivy jsou kalium šetřící diuretikum amilorid, hypolipidemikum acipimox, perorální antidiabetikum glipizid či nebenzodiazepinové hypnotikum zopiklon. Z vyvíjených látek zaslouží pozornost potenciální antineoplastikum pyrazindiazohydroxid či zajímavé antivirotikum 6-fluor-3-hydroxypyrazin-2-karboxamid.

Keywords: Klíčová slova: pyrazin, chemická léčiva, vývoj léčiv.

Published: February 1, 2006  Show citation

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Doležal M. Léčiva na bázi pyrazinu. Praktické lékárenství. 2005;1(1):16-17.
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