Prakt. lékáren. 2011; 7(1): 39-41

Huperzine A and other natural substances in treating Alzheimer's disease

PharmDr.Jan Martin, Ph.D., Mgr.Zuzana Kršková, doc.RNDr.Jaroslav Dušek, CSc.

Katedra farmakognosie, Farmaceutická fakulta v Hradci Králové

Alzheimer's disease is a progressive neurodegenerative process which affects a significant proportion of the population, particularly those

over 65 years of age. The disease is associated with deficits and disorders of a number of neurotransmitter systems, in particular the

cholinergic one. Currently, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors appear to be the most promising

therapeutic agents. Even among naturally occurring compounds, there are inhibitors of these enzymes and many of them are more

effective than those used in the medical practice. For instance, huperzine A has more profound effects and exhibits more beneficial

pharmacokinetic properties than current medications.

Keywords: Alzheimer's disease, acetylcholinesterase, alkaloids, huperzine A

Published: February 1, 2011  Show citation