Prakt. Lékáren. 2016; 12(1e) [Pediatr. praxi. 2015;16(3):168-171]

New options for treating oral candidiasis in children by using compounded medications

Zbyněk Sklenář^{1, 2}, Vladimír Ščigel³, Kateřina Horáčková^{2, 4}

¹ 1Farmakologický ústav, 1. lékařská fakulta, Univerzita Karlova, Praha

² 2Fragnerova lékárna U Černého orla, Praha

³ 3Stomatologická klinika, 1. lékařská fakulta, Univerzita Karlova, Praha

⁴ 4Katedra analytické chemie, Farmaceutická fakulta UK, Hradec Králové

Oral candidiasis treatment in neonates and infants is still a current issue. Until recently, the therapeutic solution of this disease has beenconsisting mainly in using extemporaneously prepared medicinal products in the oromucosal cavity containing non-specific antifungalagents. Although oromucosal gels and suspensions containing specific antifungal agents are not available as registered products in theCzech Republic, during the past five years got to enrichment of the portfolio for compounding with new substances. Nystatin and miconazoleare newly available for compounding and even they can be successfully used for the treatment of oromucosal candidiasis in neonates,infants, children and adults. The paper aim is to inform physicians of treatment possibilities, oromucosal candidiasis compoundedpreparations. The paper provides an overview of the available products. It focuses on the new substances – nystatin and miconazole – andpresents the current magistral formulas that can be used for the treatment of oromucosal candidiasis (thrush) and that could thus completelyreplace the widely prescribed preparations with gentian (methyl) violet. Presented formulas were created by the authors, who alsochecked in practice, the active substance for the extemporaneous preparation are currently available for routine prescription and yet fullycovered by public health insurance.

Keywords: candidiasis, neonates, magistral formulas, extemporaneous preparation, miconazole, nystatin, gentian (methyl) violet

Received: May 24, 2018; Accepted: May 24, 2018; Published: March 1, 2016  Show citation