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e4897617148020186179272
AKTUÁLNÍ71882940227121239349476596693822881
FARMAKOTERAPIE8108294022798216328488614732861965106611821310142114771581
NAKOLIK3512508018869138199266320349410
ZÁVAŽNÝ3949508018856127187249308379443
PROBLÉM4420508018858119188250305360455
MŮŽE4903508018892163217271
PŘEDSTAVOVAT5202508018859119174242298353416475543607669717
ŠPATNÁ5945508018856116179226298367
ADHERENCE6340508018867135206260323377448508562
K6930508018860
DOPORUČENÉ7018508018867137198269330401460515586640
LÉČBĚ7685508018853108168230285
PŘI7998508018858119148
ISCHEMICKÉ817350801882985144215269365394453514569
CHOROBĚ8771508018857128198260330393448
SRDEČNÍ?9245508018856117186240300371400444
PRAKTICKÉ80737159019080160258338422459552632710
LÉKÁRENSTVÍ88207159019073148228329411487589662740832869
stejných550970019060112187221306375445531
preparátů,11189700190103151228316390437512560645673
ale1828970019087121199
dokonce20659700190101187256340427499575
i2677970019048
takřka2762970019063137205255323399
dvojnásobně31989700190101175259294379451511597686773852
nižším40879700190100133198261294425
rizikem455097001906195161195263339470
úmrtí5501190019085216263318352
během9411190019088168254332463
sledování.1442119001906194173262348420494579612640
Fixní21201190019075108178264297
kombinace24551190019069153285373408493565637713
mají320711900190131203237270
samozřejmě35151190019061136267353416464540574704783
i43351190019035
své44081190019062136213
určité46601190019085132201234284359
nevýhody5501410019085163234310396481570640
(asi12271410019039106164196
nejvážnější14561410019085163196268341407492570602659691
je,21841410019030107132
že23531410019061136
v25221410019072
případě26271410019088135168255328415492
non-adherence31521410019085170256305376463548625672747832903977
pacient41621410019088161232265342426473
náhle46681410019085157241274352
neužívá5501630019086164249315349422496
více10841630019083118189265
preparátů13861630019099147224312386433507556641
najednou),20641630019097170203281371456542628667691
ale27921630019084118196
jak30251630019046117185
se32471630019071150
tedy34341630019061136226297
zdá,37691630019075161234262
pozitiva406816300190100187250285335368441515
oproti46211630019096185233317366399
volným5501850019072157192277345478
kombinacím10661850019070154286374408493566638671802
objektivně19081850019085174208286355410444517603681
převažují.26291850019089137213286359425511545578606
Závěrem5440970019086157224296339412539
je6012970019036110
tedy6155970019051123208276
možno64669700190131214273356438
konstatovat,6937970019070150233287335405449528596666710735
že7705970019067139
non-adherence7879970019086168251296365449530605648721803871942
k8855970019069
předepsané8959970019088132204289364448504575656731
léčbě52201190019034108178261337
představuje55841190019089132205290345392462529611641715
u63261190019085
pacientů64391190019088158226255329411455536
v70021190019073
sekundární71021190019059134198280362446514557640669
prevenci77981190019089133205274346428496526
poměrně83511190019088172299374417500575
zásadní89531190019064135191262346427456
medicínský94361190019013120652201410019086115181209289343405476
problém,57211410019088131209293323396521544
v62911410019071
nezanedbatelnémíře638714100190851592202903704435276106797227928229019751130115812051276
spojeným76881410019059141224253326406469597
i83171410019026
s83681410019059
rizikempředčasného8460141001903969129158220292417529572643727794862916996106911501231
úmrtí52201630019085211253305334
či55801630019071100
nefatální57061630019085160198268312381411491520
recidivy62591630019040112181210293322391464
kardiovaskulární67491630019067138181262291372439509563626707737804847930958
příhody.77331630019088132162246328413480497
Zkušenosti82561630019086149230284358439521576624653
a89351630019073
i90411630019026
objektivní90931630019085170200273337387417485568597
důkazy52201850019087167230301364437
ale56841850019073103177
prokazují,58891850019088132212276348411493523552575
že64911850019065137
ani66551850019073154183
tato68721850019043113157236
výzva71351850019073146211286356
není75181850019086161242271
v78171850019072
klinické79161850019068100129210239307370443
praxi83861850019088133203270300
nepřekonatelná.87131850019086161245289361425505588656700772802883952977
LITERATURA5522245020884132225317418533615733834949
1.550247601576787
Piepoli670247801556591153225295323349
MF,105124780155102161170
Hoes12532478015582151216264
AW,15492478015576177193
Agewall17742478015577146209303362389415
S,2219247801556385
Albus23362478015576103174243291
C,2659247801557496
Brotons27872478015566104172210277347394
C,3213247801557597
Catapano33422478015574134173232303363432502
AL,38762478015576133157
et40632478015566105
al.4198247801556188111
201643392478015565127184240
European460824780155631291672343063715502638015559128
Guidelines7142638015581150177248311339365433497546
on12892638015576146
cardiovascular14642638015565124162231257327384443491549618645703740
disease22342638015577104151214271319382
prevention26462638015578117178237299368407434503573
in32492638015533102
clinical3381263801556491117186212270329356
practice:37672638015578117176234278305363424445
The42422638015567139202
Sixth4474263801556792148192262
Joint47652638015552121148217255
Task5502798015560110158212
Force7912798015564131170226287
of11112798015569103
the12442798015543112176
European14502798015563130167235307371428497
Society19772798015564133193219282322383
of23932798015569103
Cardiology25292798015575134172241267336364434506564
and31232798015562131202
Other33582798015587130199262300
Societies36882798015564133192219282322348411459
on41802798015570139
Cardiovascular43522798015575134172241267336394454501560628550295801552886124
Disease7042958015584111158221279327390
Prevention11242958015565102164222284353392419487557
in1711295801552796
Clinical18372958015574101127197223281341368
Practice22352958015565102161219263289347408
(constituted2673295801553488154224271313339379448488549621
by33232958015572129
representatives34822958015538100171209271319382452490549588615673735784
of42952958015569103
1044282958015563120
societies45772958015549118177204267307334397445
and5503118015559128199
by7763118015571128
invited933311801552593150177217278350
experts):13103118015563120192256294339389418439
Developed17763118015584148206268296365437501573
with23763118015594121161230
the26363118015537106170
special28363118015545116180240266324350
contribution32133118015558125195233271299370439479506575645
of38843118015569104
the40173118015538107170
European42143118015561127164232304368425494
Association47353118015576126173243550327801555884142181208277346
for9263278015544113151
Cardiovascular11073278015584144181251277346404463511569638665723761
Prevention18973278015576112174232294363402429497567
&24903278015572
Rehabilitation25883278015565129198256328355382408448507546573642712
(EACPR).33293278015545104182253317381414432
Eur37913278015571137175
J39953278015555
Prev40803278015575112174232
Cardiol43423278015584144181250277346374
2016;47613278015563125182238259
23(11):5503438015563126158215263288308
Np1–np96.8893438015583155208267338409472537560
2.550359601576793
Choudhry6683598015574141210278347415451512
NK,12053598015583146171
Glynn14003598015581109165235302
RJ,17273598015566113133
Avorn18843598015576130197234303
J,2215359801554261
Lee23013598015558119182
JL,2511359801554198121
Brennan26563598015566103163231298356423
TA,31043598015560126149
Reisman32783598015566128153199303360428
L,3730359801555981
et38363598015563101
al.3962359801555985106
Untangling40933598015581148185243311381406431498568
the46893598015537105167
relationship4885359801553495550375801552784121147215283328395420489
between10633758015572135173268329392459
medication154637580155106168238263319377414440507575
adherence21453758015559128196257293353421477537
and27053758015559126196
post-myocardial29253758015571140187227260365419486543601637704729785811
infarction3764375801552390122180216271313339406474
outcomes:42623758015569137175229294399461508528
medication481437580155106167550391801557196152211248274341410
adherence9883918015559129197259295356423480540
and15563918015559127197
clinical1781391801555884108176201257315341
outcomes.21513918015569137176230295401463510532
Am27123918015576181
Heart29213918015582144200237280
J32303918015544
2014;33073918015563124179234253
167(1):35883918015563118176203258281301
51–58.e55.39173918015563117175235296318380441498518
3.550407601576792
Ho6734078015582150
PM,8554078015565162184
Spertus10674078015564133196233276344389
JA,14854078015548119143
Masoudi165940780155101159205273341411436
FA,21244078015563130153
Reid23094078015565128153222
KJ,25634078015564114134
Peterson27284078015566125163223259307375444
ED,32004078015564145162
Magid339440780155101159228253323
DJ,37484078015584123142
et39214078015563102
al.4051407801556388109
Impact41894078015530135204263320363
of45834078015569102
medication4717407801551061692392645504238015558116154179247315
therapy8944238015544112174211269339394
discontinuation1320423801557196142199264333370395463529586624649717786
on21384238015569138
mortality230842380155107175212255313339364403463
after2799423801556396140199236
myocardial306742380155107161227285344380448473529555
infarction.3651423801553198130189225280322348415484506
Arch41894238015576113168235
Intern4453423801553199135195232301
Med478642380155101163234
2006;5504398015563124188252272
166(17):8504398015564118182214269320354373
1842–1847.12514398015564118183240301355409474530537
4.550455601576692
Du6654558015584152
L,840455801555880
Cheng9444558015574140202269338
Z,1306455801557091
Zhang14214558015569136192260329
Y,1773455801556577
Li1873455801555884
Y,1980455801556577
Mei208045580155101163187
D.22914558015584102
The24164558015560130192
impact26364558015522126195253309351
of30104558015569102
medication313545580155106168238263319377414439506574
adherence37324558015559128195257293353420476535
on42914558015569137
clinical4451455801555883107174199255313338
outcomes481245580155691371755504718015558123229291338
of9174718015569102
coronary10474718015558124161227296353389450
artery1525471801555996139198235296
disease:1849471801557196142204260306368389
A22664718015576
meta-analysis.237147180155106169207265304361429486511567615639685707
Eur31074718015561125162
J32974718015545
Prev33704718015566101161218
Cardiol36174718015574132169236262329356
2017;40054718015563124179230245
24(9):42784718015564120153210241260
962–970.45664718015564127186246308366424445
5.550487601576791
Iakovou669487801552784137204260327395
I,1093487801552647
Schmidt11684878015560117185289314384423
T,1618487801556174
Bonizzoni17194878015566135204229280335402470495
E,2242487801556082
Ge23524878015581144
L,2523487801555981
Sangiorgi26324878015560119186256281349386454479
GM,31394878015581180202
Stankovic3369487801556096154222275341398424481
G,38774878015581104
et40094878015563101
al.4138487801555984106
Incidence,4272487801552794151176245307375432492511
predictors,48104878015572109170550503801557196152195260297345366
and9445038015562130200
outcome11755038015569137176230296401463
of16695038015569102
thrombosis18005038015543111148214319389459505530575
after2404503801556294138198234
successful26675038015551117174228288335382416485511
implantation32065038015530134204231287355392450487513581650
of38875038015569102
drug-eluting40215038015570107175244283348374441480506573643
stents.4692503801555292152220256305328
Jama5505198015545102206263
2005;8465198015563124188248265
293(17):11405198015563123181212267318352371
2126–2130.15395198015564119171230298353408460521542
6.550535601576793
Collet6765358015574140167192253292
JP,9965358015549113117
Montalescot114653580155101170238275333359421468525590628
G,18065358015582104
Steg19395358015564100160231
PG,21985358015570149172
Steinhubl23985358015565101160185253321387457484
SR,29105358015565127150
Fox30895358015564130184
KA,33015358015569149173
Hu35065358015582149
TF,36845358015564124131
et38445358015567106
al.3978535801556389110
Clinical4121535801557499124191216273331357
outcomes45105358015570138177231296401464511
according5505518015559116170236273341366433503
to10815518015538104
permanent12115518015572135172277335402464532569
discontinuation1807551801557096141198263332369395462529586623649716785
of26185518015569102
clopidogrel2747551801555883151222248317385456492553579
or33525518015569106
placebo3485551801557298155212272341411
in3924551801552593
the40455518015538106169
CHARISMA42405518015574153227291317374472547
trial.4816551801553875101157183204
Arch5505678015576113167235
Cardiovasc8135678015575133169237262330386445491548
Dis13895678015585111156
2009;15785678015563124188251272
102(6–7):18785678015564119177206265332388421441
485–496.23475678015563128188252318376440461
7.550583601576779
Jackevicius657583801554197154207267324350406431498543
CA,12245838015574150174
Li1422583801555884
P,1529583801556670
Tu16235838015560118
JV.17705838015540106120
Prevalence,19145838015565100160217275300362430486546565
predictors,25035838015571108168239264320362428465512534
and30615838015558126195
outcomes32805838015569137176230295400462509
of38135838015569102
primary39395838015571108134238295331392
nonadherence435558380155701382062633324004624985586265505998015558117
after696599801555991135195231
acute9565998015559116183222282
myocardial126659980155107161228286344380448473530555
infarction.1850599801552794126185222276319344412480502
Circulation2008;238159980155749913519025728334037740347053929525998015563124188252271
117(8):32525998015563110161188248278297
1028–1036.35785998015563118176236302356411469530552
8.550615601576794
Melloni67061580155101163190215283351376
C,1072615801557495
Alexander11936158015576102164220278345415477514
KP,17326158015565130135
Ou18926158015588157
FS,20756158015560115136
LaPointe22376158015558117181246272339376436
NM,26996158015583182204
Roe29296158015566134197
MT,315261580155101161174
Newby33526158015583145237308363
LK,37416158015558121146
et39136158015563101
al.4040615801555985106
Predictors41726158015565100161231257313355421458506
of47046158015569102
early48326158015563119155550631801552884
discontinuation660631801557096141198264332369395462529586623649716785
of14716318015569102
evidence-based15996318015563120147216278346403462502574633679742812
medicine243763180155107169240265321346414476
after2939631801555991135195232
acute31966318015559116184223282
coronary35046318015558124161227296353389450
syndrome.39826318015546103173243279345451513533
Am45416318015576180
J47506318015542
Cardiol48186318015574133169550647801557196164190
2009;7736478015563124188251272
104(2):10736478015564119183217277307326
175–181.14276478015564115172237291345401415
9.550663601576688
Jackevicius666663801554097153205265322348403428494539
CA,12296638015574149172
Mamdani142566380155100157261330387454478
M,192766380155100123
Tu20736638015560118
JV.22196638015540106119
Adherence23626638015575143210271308367434491550
with29356638015593119158225
statin3183663801554988146183208275
therapy34866638015535102164200258327382
in3896663801552289
elderly4009663801556288157218254280336
patients43686638015572130167192253320357405
with47966638015594119158225
and52202478015559127196
without54452478015594120159227295363402
acute58752478015559116184223282
coronary61862478015558123160227295352388449
syndromes.66642478015548105175245281347453515562584
Jama72772478015545102206263
2002;75732478015563124188246266
288(4):78682478015563123186218276305325
462–467.82212478015563128187247313378436443
10.52202636015767126151
Akincigil54022638015576129157225281307376401426
A,5859263801557699
Bowblis59892638015565134226297324348394
JR,64112638015547111135
Levin65742638015560121178204272
C,6876263801557495
Jan70002638015546103171
S,7199263801556383
Patel73132638015565121159218244
M,758826380155101123
Crystal77422638015574110171218258316342
S.8112263801556384
Long-term82252638015560127195265303342402438544
adherence87972638015561131199261297358426482542
to93672638015542108
evidence9505263801556312014752202798015571133201257317
based55672798015572131177239310
secondary59052798015551113171236305375432468529
prevention64642798015572109169226287355392417485553
therapies70462798015542110172208267337363424471
after7546279801556093137196233
acute78072798015561118185224284
myocardial812127980155107161227285344380448473529555
infarction.8704279801552997129188224279321347414483505
J92372798015547
Gen93142798015581144212
Intern955427980155299752202958015540100136205
Med2008;54542958015510116323457202958015563124188252271
23(2):60192958015564126156216246266
115–121.63132958015564111163228282333388402
11.52203116015766118137
Mayer538131180155101158212272309
O,57133118015587105
Bruthans58413118015566102170209277333400446
J,6315311801554160
Rychecká63993118015565123178245307365417476
M.689931180155101124
Změny70473118015570173235302356
úrovně74263118015569105171227296357
sekundární78073118015549110163231298368424460529554
prevence83843118015572109169225286353410469
ischemické8881311801552368125192254358383439491551
choroby9456311801555812519352203278015538105175230
srdeční5479327801554884152214272339364
mezi587232780155106169221247
lety6147327801552890128188
199563643278015563116178239
a66313278015559
2017.67193278015563124179230238
Vnitr69853278015566132157196233
Lek72473278015558118172
2018;74513278015563124179234253
64:77333278015563128148
1190–1199.79103278015563110163226294348396448511528
12.52203436015767123149
Vorlíčková53973438015573136174200225281333400456515
P,5940343801557176
Mayer605034380155101159213274310
O,63943438015588105
Bruthans65283438015571108176215283340408454
J,7010343801555171
Seidlerová71093438015566129154223249310347413470528
J,7665343801555170
Gležinský77703438015581108170223248316362414475
J,8273343801555170
Mateřánková837834380155101158196255292350417470537593652
M,906434380155101124
et92163438015569108
al.9352343801556591112
The94923438015566136198
changes52203598015558125182250319381427
in5676359801552290
achievement57903598015558115183207269326386490552620657
of64713598015569102
target6601359801553693130197259297
LDL-cholesterol69223598015558140197221281348416443505551591651687753780
levels7730359801552385141202228273
between80273598015571134173268329392460
200685113598015563123187251
and87863598015558126195
201790053598015564124179230
in9263359801552390
Czech93773598015574128188246313
patients52203758015572131168194255323360409
with56553758015594120158226
chronic59083758015558125162228296321378
coronary63123758015558123161227296353389450
heart67883758015570132188224268
disease.7082375801557096141203259306368388
CorVasa74963758015574140177243298344403
2018,79283758015564124180234255
June82123758015542110178240
6,8478375801556384
doi.org/10.1016/j.crvasa.2018.858837580155711391651862542923594054645195395936487037588018298509079441006106352203918015548107129194254310364386
05.56353918015563123143
00258063918015563128186
13.52204076015767123148
Kocianova53964078015571138196221277345413469528
E,5952407801556688
Vaclavik60684078015572127184210266322348401
J,6498407801555070
Tomkova65964078015566126231284351407466
J,7090407801555170
Ondra71944078015587157227263321
P,7544407801557175
Jarkovsky76474078015551107144198264321368421481
J,8156407801555170
Benesova82554078015571134202264311379436494
K,8777407801557195
et89014078015569107
al.9036407801556591112
Heart91824078015582144200237280
rate94904078015544103140200
is5220423801552773
a53214238015568
useful54174238015578124186219288313
marker576742380155107164200254315351
of61474238015578111
adherence62864238015568137205267304364432489548
to68634238015549114
beta-blocker70064238015580143182240279350377445503556616653
treatment7687423801554986146203240345407475512
in82284238015535103
hypertension.83594238015579132204267303347406474520545612681703
Blood90904238015574101169238309
Press94274238015574109170217263
2017;52204398015563124179230245
26(5):54944398015563122155214245264
311–318.57874398015563117164222279333387409
14.52204556015766124149
Yusuf53934558015565127172238271
S,5688455801556080
Islam579745580155236893149253
S,6074455801556081
Chow61794558015573140208300
CK,65034558015573135160
Rangarajan66864558015566124191260317353411436493560
S,7270455801556080
Dagenais73744558015584141210271339396421466
G,78644558015580103
Diaz79914558015583109165217
R,8232455801556589
et83444558015563101
al.8469455801555984105
Use85984558015581125187
of88094558015569102
secondary89344558015549111168233301371427464524
prevention9482455801557110816852204718015558117184220245311378
drugs56214718015570105172241285
for5934471801552994130
cardiovascular60874718015558115150216241307362420465521587611667702
disease6812471801557094139200255300361
in7201471801552288
the73164718015535102163
community75024718015557121225327393459484521580
in8110471801552288
high-income,8221471801556993161227265291357413477581642660
middle-income,890447180155105130198266291351391417483539603706768786
and52204878015559127196
low-income54454878015533101193232259327383449554617
countries60904878015564129197265302339365427473
(the6592487801554076144207
PURE68274878015571149213272
Study):71284878015566102170239296327346
a75024878015565
prospective76024878015571109175222291354412454480537598
epidemiological82294878015568138164234296400425493520588658684740798824
survey.90814878015555121157219280336351
Lancet9460487801556412419152205038015558117156
2011;54085038015563124179227238
378(9798):56755038015563120179211268326385447478497
1231–1243.62005038015564116178231289343395451508528
15.52205196015766123147
Williams539051980155106133158183208264368413
B,5827519801556586
Mancia593751980155100158225281306362
G,63235198015581103
Spiering64505198015560128154215252278345414
W,688751980155107121
Agabiti70325198015576144200270295334359
Rosei74155198015565133180241266
E,7705519801556082
Azizi78115198015575130156207233
M,806751980155101123
Burnier82145198015565132168237262323359
M,859751980155101123
et87435198015563101
al.8868519801555984105
201889975198015563123178232
ESC/ESH92535198015560120192239299359437
Guidelines52205358015580147171239300325349415476522
for5770535801552894130
the59285358015535102163
management611353580155106162228284352413516577643679
of68155358015568101
arterial6938535801555994136195230256311336
hypertension.72965358015569122192254289332390457501525592659680
Eur79995358015559123158
Heart81805358015581142197232275
J84825358015540
2018;85485358015563122176229248
39(33):88195358015563120152210267295313
3021–3104.91555358015563123179233290345398452515535
16.52205516015767126152
Ibanez5400551801552696155222284337
B,5764551801556586
James58795518015543100204266313
S,6219551801556182
Agewall63275518015577145207299357383408
S,6762551801556081
Antunes68705518015576144181248316378425
MJ,732255180155101146166
Bucciarelli-Ducci75145518015566134190245270326363423449474499538622691748802827
C,8368551801557495
Bueno84905518015566133195263331
H,88485518015582103
et89785518015563102
al.9107551801555984106
201792405518015563123179230
ESC94975518015560121193
Guidelines52205678015581148173242303329354421483530
for5778567801553097133
the59405678015535103165
management612956780155106163231288357418522584652688
of68415678015569101
acute69665678015559115182220280
myocardial727056780155106160226284342378446471527553
infarction7851567801552391123182218272314339407474
in8354567801552290
patients84685678015571130167192253321358406
presenting88985678015572108168215276344381406474543
with94655678015593119157225
ST-segment52205838015560121152199262332437499567604
elevation:5850583801556389151208266303329397465485
The63605838015561131193
Task65785838015561109156208
Force68125838015560126164218278
for7118583801553299136
the72825838015538106168
management747658380155106163231288358420524587654691
of81935838015569102
acute83215838015559116183222282
myocardial862958380155106160227285343380447473529555
infarction9212583801552492124183219274316342409478
in5220599801552795
patients53465998015572131168194255323360409
presenting57865998015572109169216278346383409477546
with63635998015594120158226
ST-segment66185998015563124155202264335439501569606
elevation7255599801556389151208266304329397465
of77515998015569102
the78815998015543111173
European80835998015563128164230301364420489
Society86005998015563131189215276315375
of90065998015569102
Cardiology91395998015574132169236262329356424494551
(ESC).5220615801553493153225261278
Eur55266158015561125162
Heart57166158015582144201237280
J60256158015545
2018;61026158015563124179234253
39(2):63846158015563122155215245264
119–177.66766158015564111164231285335397404
17.52206316015767122134
Richter5378631801556691148215252312348
A,5750631801557699
Anton58746318015575143180246314
SF,62126318015560116123
Koch63596318015565132189257
P,6640631801556569
Dennett67336318015584147215282344383425
SL.71826318015560115137
The73436318015561130192
impact75646318015522126196255312354
of79426318015569102
reducing8072631801553494165231288313380450
dose85466318015570138185247
frequency8821631801553068128199265327395452511
on93566318015569138
health951863180155691315220647801555985123192
outcomes.54406478015569137176230295400462509532
Clin60006478015574100125192
Ther62206478015561131193230
2003;64836478015563124188247265
25(8):67766478015564126155215245265
2307–2335;70696478015563125186244301356418476534551
discussion7648647801557196141198266312358383450519
2306.81956478015564125187250272
18.52206636015767127155
Gupta54056638015581150221261320
AK,57556638015576140166
Arshad59516638015576114164232290361
S,6343663801556082
Poulter64556638015565132201228268329366
NR.68516638015583149174
Compliance,70556638015574141248319347373431500558619639
safety,77246638015549109143205245306322
and80766638015559128199
effectiveness8305663801556398133196255298325384446515579627675
of90106638015569103
fixed-dose9143663801553263119180252292366436484547