Prakt. lékáren. 2010; 6(1): 30-35

New medicinal substances in extemporaneous prescription, part 1 - Nystatin

PharmDr.Zbyněk Sklenář, Ph.D.¹, PharmDr.Jan Hašek²

¹ Vyšší odborná škola zdravotnická, Plzeň

² Lékárna U Matky Boží, Doksy

Nystatin is a well-known and long-established antifungal drug; in the Czech Republic, however, it has been available exclusively in the form

of mass produced medicinal drugs, not as a substance for magistral preparation. Since this medication is particularly applied in candida

infections of the skin and oral cavity, it should be made available for magistral preparation of medicines in the Czech Republic, too. The

paper aims to introduce the above-mentioned substance in more detail, specify its properties, effects, and use, present some selected

prescriptions used abroad and thus bring them to the attention of both pharmacists and physicians in the Czech Republic. Moreover,

warranted shelf life periods based on the data from standardized prescriptions from abroad are listed for magistral preparations. Nystatin

prescriptions may be modified as required by the prescribing physicians, or new ones may be made provided there is sufficient

stability of the main active substance.

Keywords: nystatin, magistral preparation, candidiasis, neonates, premature infants, stability, anionic cream, gynaecological ointment

Published: March 1, 2010  Show citation