Prakt. lékáren. 2011; 7(2): 55-57
Ustekinumab - a new option of psoriasis therapy
- I. dermatovenerologická klinika LF a FN u sv. Anny v Brně
Psoriasis is a chronic inflammatory disease that can be treated with biologics. Ustekinumab is a new group of biologics called p40 blockers.
Ustekinumab is a fully human monoclonal antibody that binds to the protein subunit p40 of the interleukins IL-12 and IL-23. This results
in the blockade of the activation of T-lymphocytes that prevents their differentiation to Th1 and Th17 cells, with subsequent blocking of
secretion of proinflammatory mediators (TNF-alfa, IFN-gamma, IL-17, IL-22). Ustekinumab is administered in subcutaneous injections,
45 mg for dose (or 90 mg for dose in patients heavier than 100 kg), at weeks 0 and 4 and than once every 12 weeks.
Keywords: ustekinumab, p40 blockers, psoriasis, biologic treatment
Published: April 5, 2011 Show citation
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