Prakt. lékáren. 2021; 17(1): e33-e41 | DOI: 10.36290/lek.2021.012

The most significant side effects of non-opioid analgesics and their pharmacological mechanisms

Hana Kotolová1, Jana Nováková2
1 Ústav farmakologie a toxikologie, Farmaceutická fakulta, Masarykova univerzita, Brno
2 Farmakologický ústav, Lékařská fakulta, Masarykova univerzita, Brno

Analgesics belong to the most commonly prescribed drugs. Non-opioid analgesics are drugs of various chemical origin that have analgesic, antipyretic and some of them also have anti-inflammatory and antiaggregation effect. They can be divided into analgesics - antipyretics and non-steroidal anti-inflammatory drugs. Inhibition of cyclooxygenase and thus influencing the formation of eicosanoids is a common mechanism of action, especially in nonsteroidal antiphlogistics. Both desirable therapeutic effects and side effects are associated with the influencing of eicosanoid production.

Keywords: non-steroidal anti-inflammatory drugs, cyclooxygenase, side effects.

Published: April 15, 2021  Show citation

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Kotolová H, Nováková J. The most significant side effects of non-opioid analgesics and their pharmacological mechanisms. Praktické lékárenství. 2021;17(1):e33-41. doi: 10.36290/lek.2021.012.
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