Prakt. lékáren. 2021; 17(4): e36-e50 [Med. praxi. 2021;18(2):133-139]

Drug-induced acute kidney injury

Michal Prokeš, Josef Suchopár
DrugAgency, a. s., Praha

Drug-induced acute kidney injury (AKI) is a relatively common adverse event, and in some cases, drugs that have long-term nephroprotective properties may also contribute to it. This article provides basic information about the pathogenesis of AKI, the risk factors for AKI, and the symptoms of AKI, and contains a list of drugs that are associated with the development of AKI.

Keywords: acute kidney injury, triple-whammy, NSAID, RAAS inhibitors, diuretics.

Published: December 14, 2021  Show citation

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Prokeš M, Suchopár J. Drug-induced acute kidney injury. Praktické lékárenství. 2021;17(4):e36-50.
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    References

    1. Kolečková M, Tichý T. Polékové poškození ledvin. Klin Farmakol Farm 2018; 32: 14-19. Go to original source...
    2. Chawla LS, et al. Association between AKI and long-term renal and cardiovascular outcomes in United States veterans. Clin J Am Soc Nephrol 2014; 9: 448-456. Go to original source... Go to PubMed...
    3. Doporučení k vyšetřování glomerulární filtrace. Doporučení České nefrologické společnosti a České společnosti klinické biochemie ČLS JEP, 2013. Dostupné z: https://www.nefrol.cz/odbornici/doporucene-postupy-cns.
    4. Vachek J, et al. Akutní poškození ledvin. Kardiol Rev Int Med 2014; 16: 57-61.
    5. Wonnacott A, et al. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol 2014; 9: 1007-1014. Go to original source... Go to PubMed...
    6. Taber SS, Pasko DA. The epidemiology of drug-induced disorders: the kidney. Expert Opin Drug Saf 2008; 7: 679-690. Go to original source... Go to PubMed...
    7. Pedrós C, et al. Adverse drug reactions leading to urgent hospital admission in an elderly population: prevalence and main features. Eur J Clin Pharmacol 2016; 72: 219-226. Go to original source... Go to PubMed...
    8. Xue JL, et al. Incidence and mortality of acute renal failure in medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 2006; 17: 1135-1142. Go to original source... Go to PubMed...
    9. Prieto-García L, et al. mechanismus of triple whammy acute kidney injury. Pharmacol Ther 2016; 167: 132-145. Go to original source... Go to PubMed...
    10. Camin RM, et al. Acute kidney injury secondary to combination of renin-angiotensin systém inhibitors, diuretics and NSAIDs: "the triple whammy". Nefrologia 2015; 35: 197-206. Go to original source... Go to PubMed...
    11. Dreischulte T, et al. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin systém inhibitors in the community increases the risk of acute kidney injury. Kidney Int 2015; 88: 396-403. Go to original source... Go to PubMed...
    12. Zager RA. Pathogenetic mechanisms in nephrotoxic acute renal failure. Semin Nephrol 1997; 17: 3-14. Go to PubMed...
    13. Markowitz GS, et al. Drug-induced renal failure: a focus on tubulointerstitial disease. Clin Chim Acta 2005; 351: 31-47. Go to original source... Go to PubMed...
    14. Naughton CA. Drug-induced nephrotoxicity. Am Fam Physician 2008; 78: 743-750. Go to PubMed...
    15. Rossert J. Drug-induced acute interstitial nephritis. Kidney Int. 2001; 60: 804-817. Go to original source... Go to PubMed...
    16. Moledina DG, Perazella MA. Drug-induced acute interstitial nephritis. Clin AJ Am Soc Nephrol 2017; 12: 2046-2049. Go to original source... Go to PubMed...
    17. Douros A, et al. Drug-induced kidney injury: a large case series from the Berlin Case-Control Surveillance Study. Clin Nephrol 2018; 89: 18-26. Go to original source... Go to PubMed...
    18. Perazella MA. Pharmacology behind common drug nephrotixicities. Clin J Am Soc Nephrol 2018; 13: 1897-1908. Go to original source... Go to PubMed...
    19. Shahrbaf FG, Assadi F. Drug-induced renal disorders. J Renal Inj Prev 2015; 4: 57-60.
    20. Piereson-Marchandise M, et al. The drugs that mostly frequently induce acute kidney injury: a case-noncase study of a pharmacovigilance database. Br J Clin Pharmacol 2017; 83: 1341-1349. Go to original source... Go to PubMed...
    21. Zhang X, et al. Non-steroidal anti-inflammatory drug Induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis. BMC Nephrol 2017; 18(1): 256. doi: 10.1186/s12882-017-0673-8 Go to original source... Go to PubMed...
    22. Gayat E, et al. Impact of angiotensin-converting enzyme inhibitors or receptor blockers in post-ICU discharge outcome in patients with acute kidney injury. Intensive Care Med 2018; 44: 598-605. Go to original source... Go to PubMed...
    23. Saly DL, Perazella MA. Harnessing basic and clinic tools to evaluate SGLT2 inhibitor nephrotoxicity. Am J Physiol Renal Physiol 2017; 313: F951-F954. doi: 10.1152/ajprenal.00250.2017. Go to original source... Go to PubMed...
    24. FDA Adverse Event Reporting System (FAERS) Public Dashboad [cit. 2020-03-23]. Dostupné z: https://www.fda.gov/drugs/questions-and-answers-fdas-adverse-event-reporting-system-faers/fda-adverse-event-reporting-system-faers-public-dashboard.
    25. Perlman A, et al. Acute renal failure with sodium-glucose-cotransporter-2 inhibitors: analysis of the FDA adverse event report systém database. Nutr metqab Cardiovasc Dis 2017; 27: 1108-1113. Go to original source... Go to PubMed...
    26. FDA Drug Safety Communitation 6-14-2016: FDA strenghtens kidney warning for diabetes Medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XE). Dostupné z: https://www.fda.gov/media/98683/download.
    27. Perlman A, et al. Clinical spectrum and mechanism of acute kidney injury in patients with DM on SGLT-2 inhibitors. IMAJ 2018; 20: 513-515. Go to PubMed...
    28. EMA: EPAR-Product Information Invokana (kanagliflozin), Muntipharma 2020/2. Dostupné z: https://www.ema.europa.eu/en/medicines/human/EPAR/invokana#product-information-section
    29. Kubát K, et al. 23 případů metforminem indukované metabolické laktátové acidózy. Klin Biochem Metab 2017; 15: 77-85.
    30. Svoboda L. Poškození ledvin kontrastní látkou. Med. Pro Praxi 2007; 4: 410-415.
    31. SPC ČR: Siofor (metformin), Berlin-Chemie, 2020/7. Dostupné z: http://www.sukl.cz/modules/medication/search.php)

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