Drug-induced peripheral neuropathies

Štefan Alušík, Zoltán Paluch

Prakt. Lékáren. 2015; 11(3e)  

The paper examines drugs of individual drug classes that are most likely to cause peripheral nerve injury. The authors describe theclinical features of injury in individual drugs as well as discuss the mechanism of injury, predisposing factors, relation to dose andcumulative dose, reversibility, and importance of early recognition of nerve injury. They suggest that drug-induced neuropathies aremore frequent than currently believed.

Lyme borreliosis

MUDr. Zdeněk Prokeš

Prakt. Lékáren. 2015; 11(3e)  

3500–4000 cases are reported every year in our country. However, making correct diagnosis might be highly problematic even resultingin consequent wrong indication of antibiotic treatment The article tries to summarize current knowledge about the history,etiology, epidemiology, pathogenesis, clinical features, diagnostics and treatment of lyme borreliosis. All stages of clinical formsare described with emphasis on skin forms of disease, due to the fact, that skin manifestation of lyme borreliosis generally occursmost frequently – up to 70 % of all cases.

Differences in Pharmacokinetics in Children

MUDr. Petra Matalová, Ph.D., PharmDr. Jaroslav Matal, Ph.D.

Prakt. Lékáren. 2015; 11(3e)  

Human growth and development consists of a continuum of biologic events. The impact of these developmental changes in drugdisposition is largely related to changes in body composition (e.g. body water content, plasma protein concentrations) and functionof organs important in metabolism (e.g. the liver) and excretion (e.g. the kidney). During the first decade of life, these changes aredynamic and can be nonlinear and discordant making standardized dosing inadequate. During rapid phases of growth/developmentdrug disposition and response may be altered. The main goal is to optimize drug therapy in children. This can be achieved throughfundamental understanding...

E-verze 3/15

Prakt. Lékáren. 2015; 11(3e)