Meningococcal diseases and their prevention

Věra Pellantová

Prakt. Lékáren. 2017; 13(2e)  

The article deals with the issue of invasive meningococcal disease, discussing the diagnosis and treatment, introducing the epidemiologicalassociations, and highlighting the options of protection against one of the most serious infectious diseases.

Research of new drugs for Alzheimer’s disease

Jana Hroudová

Prakt. Lékáren. 2017; 13(2e)  

Alzheimer’s disease (AD) is the most common cause of dementia, however, the treatment AD options are limited and based on administrationof cholinesterase inhibitors and/or memantine, affecting glutamatergic system. Presented review article summarizes current approaches in theresearch of novel agents for AD treatment; it is focused on the molecules reaching the clinical trials. The most developed direction of pharmacotherapyis focused on pathologic β-amyloid (Aβ). Several perspective studies testing monoclonal Aβ antibodies and β-secretase inhibitors are ongoing. Further, new cholinesterase inhibitors, monoamine oxidase inhibitors,...

Rational use of psychotropic drugs in oncology – selected indications, interactions, tips for practice

Jana Gregorová, Petra Holečková

Prakt. Lékáren. 2017; 13(2e)  

Indications psychotropic drugs in oncology include also chemotherapy-induced neuropathy, delirium, nausea, emesis and affect appetite. Psychotropicdrugs are often used "off label" and should be used in patients to attention. Levels of some of psychotropic drugs may be affected by a number of concomitantly administered drugs due to pharmacokinetic drug interactions. Dexamethasone, phenytoin, and carbamazepineare often the co-medication with the above-mentioned indications, among the important enzyme inducers and may reduce the effect ofpsychotropic drugs. Combinations of psychotropics potentially increased risk of pharmacodynamic drug interactions.

The pharmacotherapy review in the polymorbid geriatric patient with focus on the risk of falls and its management

Jan Vosátka, Simona Dvořáčková, Josef Malý, Jozef Kolář

Prakt. Lékáren. 2017; 13(2e): e16-e24 | DOI: 10.36290/lek.2017.068  

Drug-related problems connected with falls are one of the main problems of morbidity and mortality in geriatric patients. They significantlydecrease quality of life and increase costs for additional health-care. The analysis of these drug-related problems by a pharmacist is a tool forseeking the effective pharmacotherapy and minimization of all adverse effects connected with a treatment. The goal of this statement was the revision of pharmacotherapy for geriatric patients in aftercare institution and to point out potential drug-related problems which increasethe risk of falls and also other drug-related problems with no relation to the fall. The other...

E-verze 2/17

Prakt. Lékáren. 2017; 13(2e)