Prakt. lékáren. 2015; 11(2): 52-53 [Interní Med. 2015; 17(1): 10-12]

Advances in pharmacotherapy of pain

Marek Hakl

Centrum pro léčbu bolesti, ARK, Brno

LF MU a FN u sv. Anny v Brně

In recent years, new active substances, dosage forms of previously known agents as well as new combinations of drugs have emerged

in the field of pharmacotherapy of pain. Among active substances, a new molecule in the class of opioids has been encountered

after more than 30 years. The new substance is tapentadol, a μ-opioid agonist capable of norepinephrine reuptake inhibition in the

CNS. In the field of nonopioid analgesics, aceclofenac – a selective COX-2 inhibitor – has been newly introduced to the Czech market.

In terms of treating cancer-related breakthrough pain, transmucosal fentanyls with an ultra-rapid onset of action have recently become

available. To combat opioid-induced constipation, an agent combining oxycodone with naloxone can be used, and localized

neuropathic pain can now be managed with 8% capsaicin patch.

Keywords: tapentadol, aceclofenac, 8% capsaicin, pain management, transmucosal fentanyl

Published: April 22, 2015  Show citation