Prakt. lékáren. 2021; 17(1): 7-13 | DOI: 10.36290/lek.2021.001

Possibilities and principles of vaccination against COVID-19

Michal Křupka¹, Petr Kosztyu¹, Mojmír Račanský^{1, 2*}, Jan Schovánek^3*, Kristýna Sloupenská¹, Jan Strojil^4*, Milan Raška¹

¹ Ústav imunologie Lékařské fakulty Univerzity Palackého v Olomouci

² Oddělení alergologie a klinické imunologie, Fakultní nemocnice Olomouc

³ III. interní klinika - nefrologická, revmatologická, endokrinologická, Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci

⁴ Ústav farmakologie Lékařské fakulty Univerzity Palackého v Olomouci

^* Lékaři pracující na covidových pracovištích Fakultní nemocnice Olomouc

For the majority of people, the year 2020 will be inseparably linked to the COVID-19 pandemic which was caused by SARS-CoV-2. By January 1, 2021, nearly 84 million COVID-19 cases and more than 1.8 million COVID-19 associated deaths were confirmed worldwide. Implemented intensive anti-epidemic measures contributed to temporal reduction of the infection spread but they substantially influenced the social life, education system and economy on a global scale. After the anti-epidemic measures were relaxed, virus spread rate increased in the population immediately. Initially expected elicitation of herd immunity is under doubtable. Great expectations are therefore pinned on the introduction of preventive vaccination.The first vaccines are now available, however, the distrust of a part of the general public and, unfortunately, also a part of the health-care professionals seems to be a possible obstacle for its successful use. The aim of this article is to present the topical overview of the issue of SARS-CoV-2 vaccination including basic principles of new types of gene vaccines.

Keywords: COVID-19, SARS‑CoV-2, vakccine, mRNA, adenovirus.

Published: April 15, 2021  Show citation