Prakt. lékáren. 2022; 18(1): 27-33 | DOI: 10.36290/lek.2022.004

Vitamin C, anti-infective immunity, and problems of deficiency in children

Jan Boženský1, František Kopřiva2, Lucie Kotlářová3, Pavel Kostiuk4, Zdeněk Procházka4, Jiří Slíva5
1 Dětské oddělení Nemocnice Agel, Ostrava-Vítkovice
2 Dětská klinika, Fakultní nemocnice Olomouc
3 InPharm Clinic, Jesenice u Prahy
4 Edukafarm, Praha
5 Ústav farmakologie 3. lékařské fakulty UK, Praha

Cíl studie: Zjištění výskytu snížené hladiny vitaminu C u dětí hospitalizovaných na dětských odděleních některých nemocnic na Ostravsku a Olomoucku.

Keywords: vitamin C, ascorbic acid, immunity, vitamin C deficiency, screening of vitamin C in urine, diagnostic strips for vitamin C examination in urine.

Published: March 14, 2022  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Boženský J, Kopřiva F, Kotlářová L, Kostiuk P, Procházka Z, Slíva J. Vitamin C, anti-infective immunity, and problems of deficiency in children. Praktické lékárenství. 2022;18(1):27-33. doi: 10.36290/lek.2022.004.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Vitamin C. Fact sheet for professionals. National Institues of Health/Office of Dietary Supplements. Update 2/2020. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional. Accessed 4.1.2021.
    2. Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9:1211. Go to original source... Go to PubMed...
    3. Bakaev VV, Duntau AP. Ascorbic acid in blood serum of patients with pulmonary tuberculosis and pneumonia. Int J Tuberc Lung Dis. 2004;8:263-266. Go to PubMed...
    4. Hunt C, Chakravorty NK, Annan G, et al. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam Nutr Res. 1994;64:212-219.
    5. Uesato S, Kitagawa Y, Kaijima T, et al. Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation. Cancer Lett. 2001;166:143-146. Go to original source... Go to PubMed...
    6. Cinatl J, Cinatl J, Weber B, et al. In vitro inhibition of human cytomegalovirus replication in human foreskin fibroblasts and endothelial cells by ascorbic acid 2-phosphate. Antiviral Res. 1995;27:405-418. Go to original source... Go to PubMed...
    7. Leibovitz B, Siegel BV. Ascorbic acid and the immune response. Adv Exp Med Biol. 1981;135:1-25. Go to original source... Go to PubMed...
    8. Dey S, Bishayi B. Killing of S.aureus in murine peritoneal macrophages by ascorbic acid along with antibiotics chloramphenicol or ofloxacin: correlation with inflammation. Microb Pathog. 2018;115:239-250. Go to original source... Go to PubMed...
    9. Kim Y, Kim H, Bae S, et al. Vitamin C is an essential factor on the anti-viral immune response through the production of interferon-alpha/beta at the initial stage of influenza A virus (H3N2) infection. Immune Netw. 2013;13:70-74. Go to original source... Go to PubMed...
    10. Li W, Maeda N, Beck MA. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice. J Nutr. 2006;136:2611-2616. Go to original source... Go to PubMed...
    11. Cai Y, Li YF, Tang LP, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. Go to original source... Go to PubMed...
    12. Kataoka A, Imai H, Inayoshi S, et al. Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy. J Neurol Neurosurg Psy. 1993;56:1213-1216. Go to original source... Go to PubMed...
    13. Harakeh S. NF-kappa B-independent suppression of HIV expression by ascorbic acid. AIDS Res Hum Retroviruses. 1997;13:235-239. Go to original source... Go to PubMed...
    14. Hosakote YM, Jantzi PD, Esham DL, et al. Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med. 2011;183:1550-1560. Go to original source... Go to PubMed...
    15. Cahill L, Corey PN, El Sohemy A. Vitamin C deficiency in a population of young Canadian adults. Am J Epidemiol. 2009;170:464-471. Go to original source... Go to PubMed...
    16. Kiondo P, Tumwesigye NM, Wandabwa J, et al. Plasma vitamin C assay in women of reproductive age in Kampala, Uganda, using a colorimetric method. Trop Med Int Health. 2012;17:191-196. Go to original source... Go to PubMed...
    17. Vinas BR, Barba LR, Ngo J, et al. Projected prevalence of ina¬dequate nutrient intakes in Europe. Ann Nutr Metab. 2011;59:84-95. Go to original source... Go to PubMed...
    18. Wrieden WL, Hannah MK, Bolton-Smith, et al. Plasma vitamin C and food choice in the third Glasgow MONICA population survey. J Epidemiol Community Health. 2000;54:355-360. Go to original source... Go to PubMed...
    19. Hagel AF, Albrecht H, Dauth W, et al. Plasma concentrations of ascorbic acid in a cross section of the German population. J Int Med Res. 2018;46:168-174. Go to original source... Go to PubMed...
    20. Hampl, Taylor, Johnston. Vitamin C deficiency and depletion in United states: the third National Health and Nutrition Examination Survey, 1988 to 1994. Am J Public Health. 2004;94:870-875. Go to original source... Go to PubMed...
    21. Villalpando S, Montalvo-Velarde I, Rivera JA. Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: A probabilistic national survey. Salud Publ Mex. 2003:4-5: S508-S519. Go to original source... Go to PubMed...
    22. Sivakumar B, Nair KM, Sreeramulu D, et al. Effect of micronutrient supplement on health and nutritional status of schoolchildren: biochemical status. Nutrients. 2020;12:2008.
    23. Kothari P, Tate A, Adewumi A, et al. The risk for scurvy in children with neurodevelopmental disorders. Spec Care Dentist. 2020;40:1-9. Go to original source... Go to PubMed...
    24. Ceglie G, Macchiarulo G, Marchili MR, et al. Scurvy: still a threat in the well-fed first world? Arch Dis Child. 2019;104:381-383. Go to original source... Go to PubMed...
    25. Rowe C, Carr AC. Global vitamin C status and prevalence of deficiency: a cause for concern? Nutrients. 2020;12:2008. Go to original source... Go to PubMed...
    26. Carr AC, Rowe C. Factors affecting vitamin C status and prevalence of deficiency: a global health perspective. Nutrients. 2020;12:1963. Go to original source... Go to PubMed...
    27. Jackson JA, Wong K, Krier C, et al. Screening for vitamin C in the urine: is it clinically significant? J Orthomol Med. 2005;20:259-261.
    28. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (Vitamin C) and their enhanced bioavailability. J Liposome Res. 2020;30:1-35. Go to PubMed...
    29. Lukawski M, Dalek P, Borowik T, et al. New oral liposomal vitamin C formulation: properties and bioavailability. J Liposome Res 2020; 30: 227-234. Go to original source... Go to PubMed...
    30. Padayatty J, et al. Vitamin C Pharmacokinetics: Implications for Oral nad Intravenous Use. Ann Intern Med. 2004; 140:533-537 Go to original source... Go to PubMed...
    31. Hickey S, et al. Pharmacokinetics of oral vitamin C. Journal of Nutrition and Environmental Medicine. 2008;17:169-177. Go to original source...

    Return to the content


    Pharmacy for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.