Prakt. lékáren. 2022; 18(4): 4-10 [Neurol. praxi. 2022;23(3):227-230]

Elimination half­‑life is not just a pharmacological profile

MUDr. Ondřej Strýček, Ph.D.1, 2, MUDr. Jitka Kočvarová1
1 Centrum pro epilepsie Brno, I. neurologická klinika FN u sv. Anny a Lékařské fakulty Masarykovy univerzity, Brno
2 Středoevropský technologický institut - CEITEC, Brno

When choosing the optimal drug, we focus on several key characteristics of the drug. The drug pharmacokinetic profile is usually a less significant factor in this choice. The aim of the following article is to clearly explain why we should pay particular attention to the elimination half-life as an important pharmacokinetic parameter. We also want to point out its role in anti-seizure medication, for which the stability of plasma drug levels is essential.

Keywords: elimination half­­‑life, anti­‑seizure medication, epilepsy.

Published: December 15, 2022  Show citation

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Strýček O, Kočvarová J. Elimination half­‑life is not just a pharmacological profile. Praktické lékárenství. 2022;18(4):4-10.
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