Praktické lékárenství, 2010, issue 1

Editorial

Slovo úvodem

PharmDr. Pavel Grodza

Prakt. lékáren. 2010; 6(1): 3

Current pharmacotherapy

Benign prostatic hyperplasia, diagnostics and contemporary opportunities of miniinvasive treatment

MUDr.Jiří Klečka, Ph.D., MUDr.Petr Běhounek, doc.MUDr.Milan Hora, Ph.D., MUDr.Viktor Eret

Prakt. lékáren. 2010; 6(1): 9-14

This article summarizes contemporary oppurtunities of miniinvasive treatment of the patients with benign prostate hyperplasia (BPH). Uptodate pharmacological treatment offers to the patients good quality of life and decreased the risk of surgical intervention. Nowadays is very popular combined therapy mainly combination of alpha-adrenergic blockers with 5α-reductase inhibitors or with parasympatolytics.

Constipation - a common problem

MUDr.Jan Martínek, Ph.D.

Prakt. lékáren. 2010; 6(1): 15-21

Constipation is a group of symptoms affecting up to 20% of the population. When caused by a specific disease (tumour, diverticula, narrowing of the bowel or hypothyroidism), it is referred to as secondary and treated with respect to the causative agent. Primary constipation is either caused by poor motility of the large bowel (so-called lazy bowel syndrome or inactive colon) or by difficult evacuation due to an impaired defecation reflex or an anatomical obstruction in the rectal region (= terminal constipation). A patient with chronic constipation should be examined thoroughly by his general practitioner or by a specialist – gastroenterologist....

Influenza

MUDr.Jaroslav Kapla, Ph.D.

Prakt. lékáren. 2010; 6(1): 22-24

Influenza is highly contagious infectious disease with epidemic even pandemic features of its spread. Influenza viruses are the causes of illness divided into three types A, B and C. Human is the source of illness, virus is spreaded by virus-laden aerosols or by direct contact with infected objects and susceptibility of population to infection is general. Influenza is characterized by the fever, headache, artrodynia, myalgia, chills and cough. The most frequent complication is presented by pneumonia. The rapid tests for antigen detection are used nowadays besides PCR testing and serological methods. The treatment is supportive, two classes...

Diseases of the oral mucosa

PharmDr.Jan Gajdziok, Eliška Tajovská, PharmDr.Martina Bajerová, PharmDr.Zuzana Chalupová, Ph.D.

Prakt. lékáren. 2010; 6(1): 26-29

The majority of population comes during the live across problems associated with disabilities of the oral mucosa, resulting from its permanent exposure to external factors related with food intake, breathing and speaking processes. Diseases of the oral cavity may be one of the first signs of more serious systemic disease. Healthy oral cavity could also reduce the incidence of a number of pathological conditions (cardiovascular disorders, respiratory infections, diabetes, etc.). Among the diseases affecting the oral mucosa may be included: viral diseases of erosive character, diseases of ulcerative nature, diseases which belong to so-called...

Medicamenta nova

Exenatide

prof.MUDr.Štěpán Svačina, DrSc., MBA

Prakt. lékáren. 2010; 6(1): 6-8

Therapy using incretin analogues changes the treatment possibilities in type 2 diabetes in a large extent. Exenatide is the first clinically used drug of this group. It is applied in subcutaneous injections twice daily. No hypoglycemic events are present and initial reports have been published about the use of exenatide in nondiabetic obese patients to reduce weight. The secretion of glucagon is modulated and the secretion of insulin is stimulated. The two main effects of exenatide are compensation of diabetes and weight reduction. There are also other effects: improvement of dyslipidemia and blood pressure reduction. Prescription is limited...

Phytotherapy

Modifying cholesterol level with plant substances

PharmDr.Miloš Potužák

Prakt. lékáren. 2010; 6(1): 43-45

Plant substances affect elevated serum cholesterol levels by a variety of mechanisms: they reduce intestinal cholesterol and bile acid absorption, inhibit hepatic cholesterol synthesis, protect LDL-cholesterol from oxidation, and increase HDL-cholesterol content at the expense of LDL-cholesterol.

Pharmaceutical technology

New medicinal substances in extemporaneous prescription, part 1 - Nystatin

PharmDr.Zbyněk Sklenář, Ph.D., PharmDr.Jan Hašek

Prakt. lékáren. 2010; 6(1): 30-35

Nystatin is a well-known and long-established antifungal drug; in the Czech Republic, however, it has been available exclusively in the form of mass produced medicinal drugs, not as a substance for magistral preparation. Since this medication is particularly applied in candida infections of the skin and oral cavity, it should be made available for magistral preparation of medicines in the Czech Republic, too. The paper aims to introduce the above-mentioned substance in more detail, specify its properties, effects, and use, present some selected prescriptions used abroad and thus bring them to the attention of both pharmacists and physicians...

For pharmaceutical assistants

The mucosal immune system of digestive tract, breast milk and prebiotics

prof.MUDr.František Kopřiva, Ph.D.

Prakt. lékáren. 2010; 6(1): 38-42

The development of mucosal immune system of digestive tract is by determined enviroment influences. The colonisation of digestive tract is positively regulated by breast feeding. The gut microflora is positively modulated by prebiotics. It is possible to influence the development of immunopathological reactivity in children.

Pharmacist and the Internet

Většina internetových lékáren inzerujících na vyhledávači Bing porušuje zákon

PharmDr.Martin Dočkal

Prakt. lékáren. 2010; 6(1): 52

Social pharmacy

Project Seniors

PharmDr.Lucie Stankovičová, PharmDr.Petr Lorenc

Prakt. lékáren. 2010; 6(1): 46-47

Seniors represent significant part of pharmacy clients. Higher age brings necessary unique qualities in treatment. Project Seniors wants to educate, remove communication barriers and make pharmacotherapy effective.