Farmacie pro praxi. 2023;19(1):47-50 | DOI: 10.36290/lek.2023.007

Treatment options for subthreshold anxiety: lavender oil

Vilma Vranová1, Lenka Trdlová2
1 Ústav aplikované farmacie, Farmaceutická fakulta, Masarykova univerzita, Brno
2 Psychiatrická nemocnice Bohnice

Subthreshold anxiety is among the most common mental disorders, with a two-fold higher prevalence than clinically manifested anxiety disorders. Psychological symptoms include obsessive thoughts, insomnia, restlessness, tension, irritability, and difficulty concentrating, and somatic symptoms also tend to be present. Subsyndromal anxiety should not be underestimated since it can lead to suicide; as a result, these patients require attention and timely initiation of treatment.

Keywords: subthreshold anxiety, antidepressants, lavender.

Accepted: February 17, 2023; Published: March 3, 2023  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vranová V, Trdlová L. Treatment options for subthreshold anxiety: lavender oil. Pharmacy for Practice. 2023;19(1):47-50. doi: 10.36290/lek.2023.007.
Download citation

References

  1. Votava M, Agová V, Kršiak M. Mechanizmy účinku anxiolytik. Psychiatr. prax. 2005;6(3):131-133.
  2. Racková S, Vranová V. Možnosti fytofarmak při zvládání úzkostných poruch. Prakt. lékáren. 2020;16(4):226-228.
  3. Slíva J. Pregabalin v léčbě generalizované úzkostné poruchy. Čes a slov Psychiatr. 2019;115(5):229-231.
  4. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive­‑compulsive and posttraumatic stress disorders - Version 3. Part I: Anxiety disorders.
  5. Fišar Z, Hroudová J, Raboch J. Biochemical mechanisms of action of antidepressants. Casopis Lekaru Ceskych. 150. 531-540. Export Date: 21 March 2014, Source: Scopus.
  6. Santarelli L, Saxe M, Gross C et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003;301(5634):805-9. Go to original source...
  7. Pan A, Sun Q, Czernichow S et al. Bidirectional association between depression and obesity in middle‑aged and older women. International Journal Of Obesity, 2012, 595. Go to original source...
  8. Kasper S, Müller WE, Volz HP et al. Silexan® in anxiety disorders: clinucal data and pharmacological background. World J. Biol. Psychiatr. 2018;19:412-420. Go to original source...
  9. Müller WE, Schuwald AM, Nöldner N. et al. Pharmacological basis of the therapeutical use of Silexan® (Lasea). Psychopharmakotherapie 2015.22,3-14.
  10. Mico JA, Prieto R. Elucidating the mechanism of action of pregabaliin. α(2)δ as a therapeutic target in anxiety. CNS Drugs. 2012;26:637-648. Go to original source...
  11. Schuwald AM, Nöldner, Wilmes T et al. Lavender oil­‑potent anxiolytic properties via modulating voltage dependent calcium channels. PloS One 8, 2013. e59998. https://doi.org/10.1371/journal.pone.0059998. Go to original source... Go to PubMed...
  12. Boczek T, Ferenc B, Lisek M et al. Regulation of GAP43/calmodulin complex formation via calcineurin­‑dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition. Mol. Cell. Biochem. 2015.407,251-262. Go to original source...
  13. Heiser JH, Schuwald AM, Sillani G et al. TRPC6 channel­‑mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J. Neurochem. 2013.127:303-313. Go to original source...
  14. Friedland K, Sillani G, Schuwald A, et al. Neurotrophic properrties of Silexan®, an essential oil from the flowers of lavender - preclinical evidence for antidepressant­‑like properties. Pharmacopsychiatry. 2021;54(01):37-46. Go to original source... Go to PubMed...
  15. SÚKL: Lavekan. Souhrn údajů o přípravku. [online]. [cit. 2023-01-23]. Dostupné z: https://www.sukl.cz/modules/medication/detail.php?kod=0134991.
  16. Müller WE, Sillani G, Schuwald A et al. Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender. Neurochem Int. 2021;143:104899. Go to original source...
  17. Kasper S, Erfurth A, Sachs G et al. Special issue JATROS Neurology & Psychiatry, April 2022.
  18. Gilmour H. Threshold and subthreshold Generalized Anxiety Disorder (GAD) and suicide ideation. Health Rep. 2016; 16:27(11):13-21. PMID: 27849314. Go to PubMed...




Pharmacy for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.