Magnesium supplementation: pharmacological mechanisms, routes of administration, and pitfalls

Zdeněk Zadák, Alena Tichá, Radomír Hyšpler

Prakt. Lékáren. 2018; 14(2e)  

Magnesium is a significant factor in a whole range of metabolic reactions, particularly in energy production, in mitochondrial function, beinga part of enzyme cofactors and modulating the function of transport pumps and cell membrane channels. Magnesium deficiency is verycommon in the population of industrialized countries, ranging around 33% in all male and female age groups. The diagnosis of magnesiumdepletion in the body is difficult, given that this ion is present in biological systems in several fractions and, furthermore, because its maximum is contained intracellularly. The clinical symptomatology of magnesium depletion is very broad, ranging...

Calcium and vitamin D in primary and secondary prevention of osteoporosis

Pavel Novosad

Prakt. Lékáren. 2018; 14(2e)  

The article provides information about the contemporary development of an approach to prevention of osteoporosis. It points out the developmentof opinion relevant to the issue which has been shifted today from primary prevention to the secondary one. The main goal of the primary preventionis to extend the genetically predefined time of growth of the bone tissue, thus to help prevent early osteoporosis and high-energy fractures. This preventionshould be mainly provided by the General Practitioners in cooperation with patient organisations and other mostly non-profit organisations.The main core of such prevention lays in a healthy life style, diet and...

Hypolipidemic treatment and target values of lipids

Ondřej Kyselák, Vladimír Soška

Prakt. Lékáren. 2018; 14(2e)  

Hypolipidemics are one of the most frequently prescribed drugs in the world. Last year, the updated guidelines were released: European Guidelineson cardiovascular disease prevention in clinical practice by European Society of Cardiology (ESC) and ESC/EAS (European AtherosclerosisSociety) Guidelines for the Management of Dyslipidaemias. Both of them contain changes mainly in estimation of individual cardiovascularrisk and target levels of LDL-cholesterol. Targeting these goals is usually very difficult and often impossible in patients with familial hypercholesterolemia.PCSK9 inhibitors are a new and very potent hypolipidemics that should make target...

L-tryptofan – a nutraceutical with impact on mental health

Dana Kamarádová, Vilím Šimánek

Prakt. Lékáren. 2018; 14(2e)  

L-tryptophan is an essential amino acid of the human diet. Apart from its incorporation into body proteins, L-tryptophan is the precursor ofserotonin and other neurotransmitters in the brain and gastro intestinal tract. This brief overview covers the role of L-tryptophan in brain serotoninsynthesis as an important factor in mood, cognition and social behaviour.

E-verze 2/18

Prakt. Lékáren. 2018; 14(2e)